Will we mine He3 on the moon?
Will we just do deuterium-deuterium fusion because the fuel is abundant and the output is good-enough?
Will we source tritium from… where?
Hard to be sure without knowing the exact tech developed. How efficient that is on defferent fuels will have an effect on how much effort is placed into gaining those fuels.
Of course if real options exist the easiest to obtain fuel will be used. Capatalism will ensure that. Though honestly so would most other systems.
But let’s face it. If mankind was able to generate plenty of cheap energy.
The people profiting of limited resources supply now. Will not go away. And invest what they have in controlling supply. So expect some fairly unpredictable polical moves during the roll out.
Fuel availability will be the chief driver. Terrestrially we will shift to hydrogen for portable energy.
Space now becomes a game of finding water.