Darklight? Check

Flashlight? Check

Fleshlight? ( ͡° ͜ʖ ͡°) Check.

The US is not business friendly.

Thanks for clarifying.

I don’t think the people who are prone to attribute things to Satan have much overlap with the people who work in or adjacent to pharmaceuticles. Also, what do you mean “without anything to go on”, we know exactly what’s going on. That’s why we’re talking about it.

Regulatory? Nice to hear some of you survived till today. Good luck buddy, I’m rooting for you!

Me dropping my manuscript off to my agent.

People of the same trade seldom meet together, even for merriment and diversion, but the conversation ends in a conspiracy against the public, or in some contrivance to raise prices.

-Adam Smith

Fun fact time because I’m that guy.

Coke and meth are similar in that they both activate stimulate Dopamine (reward, motivation), Norepinephrine (arousal, alertness) Serotonin (mood, modulation).

However they do it in very different ways:

Cocaine blocks neurotransmitter reuptake from the outside, it stops the neurotransmitter from being released from the synapse causing the area to flood and the synapse to fire more strongly, but still tied to normal stimulation. I.e. your body still produces the transmitter based on normal stimuli, coke just keeps it there longer, stretching the existing signal.

Methamphetamine drives release from the inside. It pushes dopamine out and into the synapse, and has some reuptake inhibition that combines drive the synapses far harder than normal. In contrast to coke, it doesn’t stretch existing signals from physiological stimuli, it makes signals regardless of what’s going on.

In short, coke blocks the sink’s drain. Meth turns on the tap and sorta plugs the drain. Slight advantage to meth here for ADHD. CNS depression that underlies it responds better to meth because the taps don’t open enough to begin with. Normal psysiological stimuli isn’t enough.

Both in theory could treat ADHD, but meth wins by a longshot because of the speed and stability of its pharmacokinetics. Coke is in and out too fast to give the user the therapeutic window of relief without causing spikes that trigger negatives like addiction or heart problems. Meth is slower and longer lasting. 20-60 mins for coke, ~4 hours for meth. Leveraging extended release (er) formulations pushes meths already superior action (turn on tap) into a daily therapeutic window, while coke is still just behaving like a party drug.

Source: Lots of personal research. ( ͡° ͜ʖ ͡°)

I remember reading an article is a pop psychology magazine talking about the emergence of what was dubbed “climate anxiety”. The APA decided it did not belong in the DSM-V because it was not a mental illness, rather a natural healthy response to an overwhelmingly damaging and intractable threat.

Or just dump them. (Drugs and Alcohol) /s

I’d rather see a full curve on a chart from 0-100, preferably with multiple curves for outdoor temp variance. -20, -10, 0 10, 20, 30. I don’t want cherry picked data. Give me the full picture, in one picture.

This is called Leadership.

Threaten me with a good time will you?

Headquartered in San Francisco, America’s values and Wikipedia’s values are not aligned. Quite a few Institutions would be well served by moving.

All True. But the severity of consequences, who feels them and how do we fix or replace the systems are all soft problems. They all have solutions, and aren’t any harder than we want to make them.

It’s worth delineating hard problems vs soft problems. A hard problem are things like climate change. Fundamental, unavoidable issues with systemic consequences for everyone.

Then there are soft problems. where man made systems abused by man made corruption become unstable. They really boil down to who is holding left holding the bag. The rich wants to be bailed out and leave the poor to suffer the consequences. The poor think the rich who shit the bed can lie in it.

Debt bombs are a soft problem. Nothing to get worked up over. Just be ready to practice what you preach when the soft problems come.

Why does the Van Allen belt look so much like booty? Stupid sexy radiation.

Beff Juck Fezos

So we can consider our sun dying and Andromeda colliding with the milky way as crappy backstops.5 billion years for a maybe is not great. I don’t know about you, but I don’t have that kind of patience. We need fresh ideas. I like your singularity idea, but getting crushed isn’t as artistically coherent as a quality shattering and if you’ve checked the price of singularities these days, its not really in the budget.

I think the most viable option I’ve heard so far is a mega asteroid. Do you know any suitable candidates for rent?

Ladies, Gentlemen, Nuclear Engineers, Aliens bent on conquest and demi-gods or demons bent on wrath and destruction; Look, we have a job to do. The earth probably isn’t going to shatter on its own. At least not with that attitude. We need teamwork. Collaboration. Hard math. Next, next-next-next-gen explosives and a lot of them.

We can do this!