It’s the scratchpad script where you copy/paste into the about:config console. I just did it for the new v.115 release. I’ve done it previously but I don’t have any set schedule. I guess 1x every six months (2x/year) seems sufficient but I wanted to see what others do.
The wiki says you run prefsCleaner.sh after you run updater.sh .
Have you read the wiki properly?
There’s also no need to do cleanup.js or whatever.